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A second major advance is our ability to systematically define and validate causal gene variants with increasing precision, power, and efficiency. In the case of isogenic cohorts of mice and rats, the analysis of single genomes can be extended to multiple time points during development, aging, and in the progression of blinding diseases, making it possible to study gene-by-environmental and gene-by-treatment effects in ways that have high translational relevance to human clinical disease. We are now at the point that is practical to consider in-depth analyses across large cohorts of human populations and rodent models. Over this same period, the costs of generating high-quality phenome and genome data have been decreased, and data quality and throughput have improved greatly. Since the first wave of whole genome sequencing in the early 2000s, teams of investigators have developed open genetic, genomic, and transcriptomic resources to study the eye, visual system, and blinding diseases. The role of three of these gene variants in glaucoma is discussed, along with the pathways activated in the disease process. The power of this experimental approach to precision medicine is highlighted by recent studies that defined cadherin 11 ( Cdh11) and a calcium channel ( Cacna2d1) as genes modulating IOP, Pou6f2 as a genetic link between CCT and retinal ganglion cell (RGC) death, and Aldh7a1 as a gene that modulates the susceptibility of RGCs to death after elevated IOP. The BXD family was exploited to define key gene variants and then establish linkage to glaucoma in human cohorts.
Recent studies focused on retinal ganglion cells and glaucoma risk factors, including intraocular pressure (IOP), central corneal thickness (CCT), and susceptibility of cellular stress. Over the past 16 years, our group has integrated powerful murine resources and web-accessible tools to identify networks modulating visual system traits-from photoreceptors to the visual cortex.
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System Requirements: Pentium Processor, Microsoft Windows 98/NT/2000/ME/XP (Not Compatible with Mac Systems), 128 MB RAM (Recommended), 300 MB free hard drive space, 800 X 600 16 bit graphic driver (True Color Recommended), Mouse or other pointing device, CD-Rom Drive.We illustrate the growing power of the BXD family of mice (recombinant inbred strains from a cross of C57BL/6J and DBA/2J mice) and companion bioinformatic tools to study complex genome-phenome relations related to glaucoma.
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Select from over 1,500 items with full color images. It is a perfect companion to the Ty Beanies Tracker Guide.
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Ty Beanie Tracker Guide 2nd Edition includes: ? Beanie Babies, Beanie Buddies, Beanie Kids ? Beanie Boppers and Teenie Beanies ? Current Secondary Market Prices ? New Improved Full-Color Pictures ? Early items & Variations ? Special Checklists and Indexes ? The best TY websites on the Internet Ty Beanies Tracker Software is an inventory and pricing tool deigned just for you, the Ty Beanies collector. Ty Beanies Tracker Guides are also packed with thousands of fabulous 4-color photographs, up-to-date secondary market prices, and important news and information.
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